Article

The role of germline-encoded T cell receptor complementarity determining regions in T cell selection and function

2013-01-01

Abstract excerpt

αβ T cell Receptors (TCR) recognise peptide antigen (p) presented on Major Histocompatability Complexes (MHC) via Complementarity Determining Regions (CDRs). TCRs are required to respond to a vast plethora of differing antigens and the CDR regions are suitably diverse, encoded by an array of gene-segments, which recombine during T cell development to generate diverse repertoires of TCRs. CDR1 and 2, which predomin...

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Identifiers and source

Literature Corpus work: 087ff6c4-67c8-5b80-aabe-9e1ea1196c57
DOI: 10.25560/10725

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