Dynamics of heavy chain junctional length biases in antibody repertoires

Abstract excerpt

Abstract Antibody variable domain sequence diversity is generated by recombination of germline segments. The third complementarity-determining region of the heavy chain (CDR H3) is the region of highest sequence diversity and is formed by the joining of heavy chain V H , D H and J H germline segments combined with random nucleotide trimming and additions between these segments. We show that CDR H3 and junctional...

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