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Article

Incorporation of multiple diversity genes in the TCRδ chain is highly regulated and evolutionarily conserved.

Journal of immunology (Baltimore, Md. : 1950) - 7 Jun 2026

Rezwani Moosa, Verdebout Isoline, Tafesse Yohannes, Papadopoulou Maria, Sanchez Sanchez Guillem, Vermijlen David

Abstract excerpt

In the canonical model of VDJ recombination, a single diversity (D) gene is incorporated into the complementarity-determining region 3 (CDR3) to produce a T cell receptor δ (TCRδ; TRD) or TCRβ (TRB) chain. But by constructing a dataset of more than 2.7 million TRD CDR3 sequences from 6 species (human, mouse, cattle, sheep, naked mole-rat, and rabbit), we found that incorporation of more than one D gene in the...

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Source

Identifiers

PMID: 42358008
DOI: 10.1093/jimmun/vkag137

Genes

TRD
TRB
LIN28B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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