Article
Chicken T-cell receptor beta-chain diversity: an evolutionarily conserved D beta-encoded glycine turn within the hypervariable CDR3 domain.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1991
McCormack W T, Tjoelker L W, Stella G, Postema C E, Thompson C B
Abstract excerpt
Unlike mammals, chickens generate an immunoglobulin (Ig) repertoire by a developmentally regulated process of intrachromosomal gene conversion, which results in nucleotide substitutions throughout the variable regions of the Ig heavy- and light-chain genes. In contrast to chicken Ig genes, we sho...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Biological Evolution
- Chick Embryo
- Chickens
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Genetic Variation
- Glycine
- Major Histocompatibility Complex
- Molecular Sequence Data
- Oligonucleotide Probes