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Article

Chicken T-cell receptor beta-chain diversity: an evolutionarily conserved D beta-encoded glycine turn within the hypervariable CDR3 domain.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1991

McCormack W T, Tjoelker L W, Stella G, Postema C E, Thompson C B

Abstract excerpt

Unlike mammals, chickens generate an immunoglobulin (Ig) repertoire by a developmentally regulated process of intrachromosomal gene conversion, which results in nucleotide substitutions throughout the variable regions of the Ig heavy- and light-chain genes. In contrast to chicken Ig genes, we show in this report that diversity of the rearranged chicken T-cell receptor (TCR) beta-chain gene is generated by...

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Identifiers

PMID: 1652759
DOI: 10.1073/pnas.88.17.7699
PMCID: PMC52369

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