Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replacement of TCR Dβ With Immunoglobulin DH DSP2.3 Imposes a Tyrosine-Enriched TCR Repertoire and Adversely Affects T Cell Development.

Frontiers in immunology - 1 Jan 2020

Levinson Michael, Khass Mohamed, Burrows Peter D, Schroeder Harry W

Abstract excerpt

Enrichment for tyrosine in immunoglobulin CDR-H3 is due in large part to natural selection of germline immunoglobulin DH sequence. We have previously shown that when DH sequence is modified to reduce the contribution of tyrosine codons, epitope recognition is altered and B cell development, antibody production, autoantibody production, and morbidity and mortality following pathogen challenge are adversely...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complementarity Determining Regions
Share to Genes, Immunoglobulin Heavy Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, T-Cell Receptor beta

Share to Immunization

Share to Immunodominant Epitopes

Share to Ovalbumin

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Thymocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 33133088
DOI: 10.3389/fimmu.2020.573413
PMCID: PMC7550431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replacement of TCR Dβ With Immunoglobulin DH DSP2.3 Imposes a Tyrosine-Enriched TCR Repertoire and Adversely Affects T Cell Development.PMID 33133088Read ↗

The sequences encoded by immunoglobulin diversity (DH) gene segments play key roles in controlling B‐cell development, antigen‐binding site diversity, and antibody productionSemantic proximity Read ↗

Preimmune Control of the Variance of TCR CDR-B3: Insights Gained From Germline Replacement of a TCR Dβ Gene Segment With an Ig D H Gene Segment.Semantic proximity Read ↗

The evolutionary and structural 'logic' of antigen receptor diversity.Semantic proximity Read ↗

Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencingSemantic proximity Read ↗

HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence.Semantic proximity Read ↗

Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencingSemantic proximity Read ↗

Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoireSemantic proximity Read ↗

Similarity and divergence in the development and expression of the mouse and human antibody repertoires.Semantic proximity Read ↗

A Broad Role for Cysteines in Bovine Antibody DiversitySemantic proximity Read ↗

MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4+ T cells.Semantic proximity Read ↗

The Cyclin D3 Protein Enforces Monogenic TCRβ Expression by Mediating TCRβ Protein-Signaled Feedback Inhibition of Vβ Recombination.Semantic proximity Read ↗

Humanized V(D)J-rearranging and TdT-expressing Mouse Vaccine Models with Physiological HIV-1 Broadly Neutralizing Antibody PrecursorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.