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Article

Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice.

Nature - 1 Jan 2000

Nishimoto H, Kikutani H, Yamamura K, Kishimoto T

Abstract excerpt

The NOD (non-obese diabetic) mouse spontaneously develops insulin-dependent diabetes mellitus (IDDM) characterized by autoimmune insulitis, involving lymphocytic infiltration around and into the islets followed by pancreatic beta (beta) cell destruction, similar to human IDDM. Genetic analysis in breeding studies between NOD and C57BL/6 mice has demonstrated that two recessive genes on independent chromosomes...

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Identifiers

PMID: 3302721
DOI: 10.1038/328432a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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