Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice.

doi:10.1038/328432a0

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Article

Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice.

Nature - 1 Jan 2000

Nishimoto H, Kikutani H, Yamamura K, Kishimoto T

Abstract excerpt

The NOD (non-obese diabetic) mouse spontaneously develops insulin-dependent diabetes mellitus (IDDM) characterized by autoimmune insulitis, involving lymphocytic infiltration around and into the islets followed by pancreatic beta (beta) cell destruction, similar to human IDDM. Genetic analysis in...

Topics

Animals
Autoimmune Diseases
Diabetes Mellitus, Experimental
Diabetes Mellitus, Type 1
Female
Histocompatibility Antigens Class II
Islets of Langerhans
Major Histocompatibility Complex
Mice
Phenotype
T-Lymphocytes
Transformation, Genetic

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