Article
Disease-protected major histocompatibility complex Ea-transgenic non-obese diabetic (NOD) mice show interleukin-4 production not seen in susceptible Ea-transgenic and non-transgenic NOD mice.
Immunology - 1 Sept 1998
Brenden N, Böhme J
Abstract excerpt
The non-obese diabetic (NOD) mouse is an animal model for insulin-dependent diabetes that has many similarities to the human disease. NOD mice transgenic for the Ea gene, allowing expression of the E molecule, are protected from diabetes and rarely develop insulitis. An Ea transgene mutated in th...
Topics
- Animals
- Cells, Cultured
- Diabetes Mellitus, Type 1
- Enzyme-Linked Immunosorbent Assay
- Gene Expression
- Genetic Predisposition to Disease
- HLA Antigens
- Histocompatibility Antigens Class I
- Interferon-gamma
- Interleukin-4
- Mice