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Article

MHC-linked protection from diabetes dissociated from clonal deletion of T cells.

Science (New York, N.Y.) - 20 Jul 1990

Böhme J, Schuhbaur B, Kanagawa O, Benoist C, Mathis D

Abstract excerpt

The I-E molecule of the major histocompatibility complex (MHC) can prevent the spontaneous development of diabetes in nonobese diabetic (NOD) mice. The mechanism of this protection has been investigated by breeding wild-type and promoter-mutated E kappa alpha transgenes onto the NOD genetic background. Animals carrying the various mutated transgenes expressed I-E on different subsets of immunocompetent cells, and...

Topics

Animals
Clone Cells
Crosses, Genetic
Diabetes Mellitus, Experimental
Genes, MHC Class II
Histocompatibility Antigens Class II
Islets of Langerhans
Major Histocompatibility Complex
Mice
Mice, Mutant Strains
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Promoter Regions, Genetic

Receptors, Antigen, T-Cell

T-Lymphocytes

Thymus Gland

Source

Identifiers

PMID: 2115690
DOI: 10.1126/science.2115690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2115690-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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