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Article

MHC-linked protection from diabetes dissociated from clonal deletion of T cells.

Science (New York, N.Y.) - 20 Jul 1990

Böhme J, Schuhbaur B, Kanagawa O, Benoist C, Mathis D

Abstract excerpt

The I-E molecule of the major histocompatibility complex (MHC) can prevent the spontaneous development of diabetes in nonobese diabetic (NOD) mice. The mechanism of this protection has been investigated by breeding wild-type and promoter-mutated E kappa alpha transgenes onto the NOD genetic background. Animals carrying the various mutated transgenes expressed I-E on different subsets of immunocompetent cells, and...

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Source

Identifiers

PMID: 2115690
DOI: 10.1126/science.2115690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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