Article
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice.
Nature - 21 Jun 1990
Miyazaki T, Uno M, Uehira M, Kikutani H, Kishimoto T, Kimoto M, Nishimoto H, Miyazaki J, Yamamura K
Abstract excerpt
Insulin-dependent diabetes mellitus is characterized by the infiltration of lymphocytes into the islets of Langerhans of the pancreas (insulitis) followed by destruction of insulin-secreting beta-cells leading to overt diabetes. The best model for the disease is the non-obese diabetic (NOD) mouse. Two unusual features of the class II major histocompatibility complex (MHC) of the NOD mouse are the absence of I-E...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.