Article
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice.
Nature - 21 Jun 1990
Miyazaki T, Uno M, Uehira M, Kikutani H, Kishimoto T, Kimoto M, Nishimoto H, Miyazaki J, Yamamura K
Abstract excerpt
Insulin-dependent diabetes mellitus is characterized by the infiltration of lymphocytes into the islets of Langerhans of the pancreas (insulitis) followed by destruction of insulin-secreting beta-cells leading to overt diabetes. The best model for the disease is the non-obese diabetic (NOD) mouse...
Topics
- Animals
- Aspartic Acid
- Base Sequence
- Diabetes Mellitus, Experimental
- Diabetes Mellitus, Type 1
- Female
- Gene Expression
- Histocompatibility Antigens Class II
- Islets of Langerhans
- Lymphocytes
- Male
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Protein Conformation