Article
Reduction in diabetes incidence in an I-Ag7 transgenic nonobese diabetic mouse line.
Diabetes - 1 Dec 1997
Wherrett D K, Singer S M, McDevitt H O
Abstract excerpt
Susceptibility to IDDM is strongly associated with major histocompatibility complex (MHC) class II genotypes. Nonobese diabetic (NOD) mice develop a similar autoimmune diabetes and have a unique MHC class II I-A allele that is required for the development of diabetes. A number of groups have shown that the introduction of resistant MHC class II alleles as transgenes into the NOD mouse protects from diabetes. We...
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