Article
Effect of X- and Y-box deletions on the development of diabetes in H-2Ealpha-chain transgenic nonobese diabetic mice.
Scandinavian journal of immunology - 1 Jan 2006
O'Shea H, Yousaf N, Altmann D, Fehervari Z, Tonks P, Hetherington C, Harach S, Bland C, Cooke A, Lund T
Abstract excerpt
The development of type 1 diabetes in nonobese diabetic (NOD) mice is influenced by major histocompatibility complex (MHC) class II genes. The NOD-E transgenic mouse, which expresses H2-E as a result of the introduction of an Ead gene, is protected from development of type 1 diabetes. While the mechanism of protection remains unclear, the effect has been regarded as a model system for MHC protection from...
Topics
- Animals
- Cyclophosphamide
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- H-2 Antigens
- Immunohistochemistry
- Mice
- Mice, Inbred NOD
- Mice, Transgenic
- Mutation
- Promoter Regions, Genetic
- Sequence Deletion
- Spleen