Article
Effect of X- and Y-box deletions on the development of diabetes in H-2Ealpha-chain transgenic nonobese diabetic mice.
Scandinavian journal of immunology - 1 Jan 2006
O'Shea H, Yousaf N, Altmann D, Fehervari Z, Tonks P, Hetherington C, Harach S, Bland C, Cooke A, Lund T
Abstract excerpt
The development of type 1 diabetes in nonobese diabetic (NOD) mice is influenced by major histocompatibility complex (MHC) class II genes. The NOD-E transgenic mouse, which expresses H2-E as a result of the introduction of an Ead gene, is protected from development of type 1 diabetes. While the mechanism of protection remains unclear, the effect has been regarded as a model system for MHC protection from...
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