Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain.

doi:10.1038/345727a0

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Article

Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain.

Nature - 21 Jun 1990

Lund T, O'Reilly L, Hutchings P, Kanagawa O, Simpson E, Gravely R, Chandler P, Dyson J, Picard J K, Edwards A

Abstract excerpt

Insulin-dependent diabetes mellitus (IDDM) is a disease with an autoimmune aetiology. The inbred non-obese diabetic (NOD) mouse strain provides a good animal model of the human disease and genetic analysis suggests that, as in man, at least one of the several genes controlling the development of...

Topics

Animals
Base Sequence
Cloning, Molecular
Diabetes Mellitus, Experimental
Diabetes Mellitus, Type 1
Female
Gene Expression
Histocompatibility Antigens Class II
Islets of Langerhans
Lymphocytes
Male
Mice
Mice, Transgenic
Molecular Sequence Data

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Restriction Mapping

Salivary Glands

Source

Open in PubMed

Identifiers

PMID: 2163026
DOI: 10.1038/345727a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2163026-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.