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Article

The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells.

Nature communications - 6 Oct 2020

Moody Jasmine C, Qadota Hiroshi, Reedy April R, Okafor C Denise, Shanmugan Niveda, Matsunaga Yohei, Christian Courtney J, Ortlund Eric A, Benian Guy M

Abstract excerpt

PIX proteins are guanine nucleotide exchange factors (GEFs) that activate Rac and Cdc42, and are known to have numerous functions in various cell types. Here, we show that a PIX protein has an important function in muscle. From a genetic screen in C. elegans, we found that pix-1 is required for the assembly of integrin adhesion complexes (IACs) at borders between muscle cells, and is required for locomotion of...

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Identifiers

PMID: 33024114
DOI: 10.1038/s41467-020-18852-4
PMCID: PMC7538588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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