Article
A tension-induced mechanotransduction pathway promotes epithelial morphogenesis.
Nature - 3 Mar 2011
Zhang Huimin, Landmann Frédéric, Zahreddine Hala, Rodriguez David, Koch Marc, Labouesse Michel
Abstract excerpt
Mechanotransduction refers to the transformation of physical forces into chemical signals. It generally involves stretch-sensitive channels or conformational change of cytoskeleton-associated proteins. Mechanotransduction is crucial for the physiology of several organs and for cell migration. The extent to which mechanical inputs contribute to development, and how they do this, remains poorly defined. Here we...
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