Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations.

doi:10.1534/g3.112.004416

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Article

Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations.

G3 (Bethesda, Md.) - 1 Feb 2013

Peters Eldon C, Gossett Andrea J, Goldstein Bob, Der Channing J, Reiner David J

Abstract excerpt

p21-activated kinases (Paks) are prominent mediators of Rac/Cdc42-dependent and -independent signaling and regulate signal transduction and cytoskeletal-based cell movements. We used the reproducible migrations of the Caenorhabditis elegans gonadal distal tip cells to show that two of the three nematode Pak proteins, MAX-2 and PAK-1, function redundantly in regulation of cell migration but are regulated by very...

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PMID: 23390595
DOI: 10.1534/g3.112.004416
PMCID: PMC3564979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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