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Article

β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo.

Nature communications - 27 Nov 2020

Omelchenko Tatiana, Hall Alan, Anderson Kathryn V

Abstract excerpt

Coordinated directional migration of cells in the mesoderm layer of the early embryo is essential for organization of the body plan. Here we show that mesoderm organization in mouse embryos depends on β-Pix (Arhgef7), a guanine nucleotide exchange factor for Rac1 and Cdc42. As early as E7.5, β-Pix mutants have an abnormally thick mesoderm layer; later, paraxial mesoderm fails to organize into somites. To define...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33247143
DOI: 10.1038/s41467-020-19889-1
PMCID: PMC7695707

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