Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A PDZ-RapGEF promotes synaptic development in Caenorhabditis elegans through a Rap/Rac signaling pathway.

Development (Cambridge, England) - 15 Aug 2025

Lamb Reagan, Scales Michael, Watkins Julie, Werner Martin, Cherra Salvatore J

Abstract excerpt

Small G proteins coordinate the development of nerve terminals. The activity of G proteins is finely tuned by GTPase regulatory proteins. Previously, we have observed that PXF-1, a Caenorhabditis elegans GTPase regulatory protein, is required for the function of cholinergic motor neurons. Here, we investigated how PXF-1 coordinates the development of presynaptic terminals at the molecular level. We observed that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to PDZ Domains

Share to Presynaptic Terminals

Share to rac GTP-Binding Proteins

Share to rap GTP-Binding Proteins

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 40748210
DOI: 10.1242/dev.204678
PMCID: PMC12448318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A PDZ-RapGEF promotes synaptic development in Caenorhabditis elegans through a Rap/Rac signaling pathway.PMID 40748210Read ↗

Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.Semantic proximity Read ↗

Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans.Semantic proximity Read ↗

Neuronally expressed Ras-family GTPase Di-Ras modulates synaptic activity in Caenorhabditis elegans.Semantic proximity Read ↗

Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix.Semantic proximity Read ↗

Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway.Semantic proximity Read ↗

Caenorhabditis elegans wsp-1 regulation of synaptic function at the neuromuscular junction.Semantic proximity Read ↗

The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans.Semantic proximity Read ↗

Regulation of retrograde signaling at neuromuscular junctions by the novel C2 domain protein AEX-1.Semantic proximity Read ↗

rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans.Semantic proximity Read ↗

PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C. elegans.Semantic proximity Read ↗

RPM-1, a Caenorhabditis elegans protein that functions in presynaptic differentiation, negatively regulates axon outgrowth by controlling SAX-3/robo and UNC-5/UNC5 activity.Semantic proximity Read ↗

RHGF-2 is an essential Rho-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1 in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.