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A PDZ-RapGEF promotes synaptic development in Caenorhabditis elegans through a Rap/Rac signaling pathway.

Development (Cambridge, England) - 15 Aug 2025

Lamb Reagan, Scales Michael, Watkins Julie, Werner Martin, Cherra Salvatore J

Abstract excerpt

Small G proteins coordinate the development of nerve terminals. The activity of G proteins is finely tuned by GTPase regulatory proteins. Previously, we have observed that PXF-1, a Caenorhabditis elegans GTPase regulatory protein, is required for the function of cholinergic motor neurons. Here, we investigated how PXF-1 coordinates the development of presynaptic terminals at the molecular level. We observed that...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Signal Transduction
Guanine Nucleotide Exchange Factors
Synapses
rac GTP-Binding Proteins
Presynaptic Terminals
Mutation
rap GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

PDZ Domains

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Identifiers

PMID: 40748210
DOI: 10.1242/dev.204678
PMCID: PMC12448318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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