Article

Parallel Rap1>RalGEF>Ral and Ras signals sculpt the <i>C. elegans</i> nervous system

2021-02-04

Abstract excerpt

<h4>ABSTRACT</h4> Ras is the most commonly mutated oncogene in humans and uses three oncogenic effectors: Raf, PI3K, and RalGEF activation of Ral. Understanding the importance of RalGEF>Ral signaling in cancer is hampered by the paucity of knowledge about their function in animal development, particularly in cell movements. We found that mutations that disrupt function of RalGEF or Ral enhance migration phenotype...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bf243d5b-f280-5fc3-b596-cd802a9a1f03
DOI: 10.1101/2021.02.04.429158

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Parallel Rap1>RalGEF>Ral and Ras signals sculpt the <i>C. elegans</i> nervous systemDOI 10.1101/2021.02.04.429158Read

FGF-dependent, polarized SOS activity orchestrates directed migration of <i>C. elegans</i> muscle progenitors independently of canonical effectors <i>in vivo</i>Semantic proximity Read

RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.Semantic proximity Read

Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans.Semantic proximity Read

The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans.Semantic proximity Read

The Atypical Rho GTPase CHW-1 Works With SAX-3/Robo to Mediate Axon Guidance in <i>Caenorhabditis elegans</i>Semantic proximity Read

A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways.Semantic proximity Read

The RhoGAP myosin 9/HUM-7 integrates membrane signals to modulate Rho/RHO-1 during embryonic morphogenesis in <i>C. elegans</i>Semantic proximity Read

The <i>C. elegans</i> NF2/Merlin Molecule NFM-1 Non-Autonomously Regulates Neuroblast Migration and Interacts Genetically with the Guidance Cue SLT-1/SlitSemantic proximity Read

RHGF-2 is an essential Rho-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1 in Caenorhabditis elegans.Semantic proximity Read

The RhoGAP HUM-7/Myo9 integrates signals to modulate RHO-1/RhoA during embryonic morphogenesis in Caenorhabditis elegansSemantic proximity Read

A thirty-year quest for a role of R-Ras in cancer: from an oncogene to a multitasking GTPase.Semantic proximity Read

RhoA activation during polarization and cytokinesis of the early <i>Caenorhabditis elegans</i> embryo is differentially dependent on NOP-1 and CYK-4Semantic proximity Read