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Article

PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.

Current biology : CB - 22 Feb 2011

Chartier Nicolas T, Salazar Ospina Diana P, Benkemoun Laura, Mayer Mirjam, Grill Stephan W, Maddox Amy S, Labbé Jean-Claude

Abstract excerpt

BACKGROUND: The serine/threonine kinase LKB1 regulates cell growth and polarity in metazoans, and loss of LKB1 function is implicated in the development of some epithelial cancers. Despite its fundamental role, the mechanism by which LKB1 regulates polarity establishment and/or maintenance is unclear. In the present study, we use the nematode C. elegans to investigate the role of the LKB1 ortholog PAR-4 in...

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Identifiers

PMID: 21276723
DOI: 10.1016/j.cub.2011.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.PMID 21276723Read ↗

The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.Semantic proximity Read ↗

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PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.Semantic proximity Read ↗

A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans.Semantic proximity Read ↗

The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry.Semantic proximity Read ↗

Apical PAR complex proteins protect against programmed epithelial assaults to create a continuous and functional intestinal lumenSemantic proximity Read ↗

MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases.Semantic proximity Read ↗

Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans.Semantic proximity Read ↗

The PAR proteins: fundamental players in animal cell polarization.Semantic proximity Read ↗

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