IPMK-1 (inositol phosphate multikinase) is required for integrin adhesion complex organization and muscle cell adhesion in Caenorhabditis elegans.

Abstract excerpt

Integrin adhesion complexes (IACs) are a network of proteins that anchor cells to the extracellular matrix. In Caenorhabditis elegans muscle IACs exist at the bases of dense bodies and M-lines, and at the boundaries of adjacent muscle cells (MCBs). Proper assembly of IACs requires the RacGEF PIX-1 and members of the PIX-1 pathway. We report that investigation into the original Million Mutation Project strain that...

Topics

• Animals
• Caenorhabditis elegans
• Caenorhabditis elegans Proteins
• Phosphotransferases (Alcohol Group Acceptor)
• Cell Adhesion
• Integrins
• Muscle Cells
• Mutation
• Muscles