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Allele-Specific Quantification of HLA-DRB1 Transcripts Reveals Imbalanced Allelic Expression That Modifies the Amino Acid Effects in HLA-DRβ1.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Mar 2021

Chun Sehwan, Bang So-Young, Ha Eunji, Cui Jing, Gu Ki-Nam, Lee Hye-Soon, Kim Kwangwoo, Bae Sang-Cheol

Abstract excerpt

OBJECTIVE: HLA association fine-mapping studies have shown the effects of missense variants in HLA-DRB1 on rheumatoid arthritis (RA) susceptibility, prognosis, and autoantibody production. However, the phenotypic effects of expression changes in HLA-DRB1 remain poorly understood. Therefore, we investigated the allele-specific expression of HLA-DRB1 and its effect on an HLA-DRβ1 structure-associated trait in RA....

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PMID: 33002286
DOI: 10.1002/art.41535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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