Article
HLA-C alleles confer risk for anti-citrullinated peptide antibody-positive rheumatoid arthritis independent of HLA-DRB1 alleles.
Rheumatology (Oxford, England) - 1 Nov 2013
Nordang Gry B N, Flåm Siri T, Maehlen Marthe T, Kvien Tore K, Viken Marthe K, Lie Benedicte A
Abstract excerpt
OBJECTIVE: The MHC exerts the greatest contribution to RA susceptibility, where certain HLA-DRB1 alleles confer the greatest risk. Interestingly, there is evidence for more risk factors in the MHC with regions surrounding the HLA class I loci, but whether these antigen-presenting loci could be causal risk variants has not been directly investigated. In this study we investigate the HLA association by direct...
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