Article
An association between amino acid position 74 of HLA-DRB1 and anti-citrullinated protein antibody levels in Japanese patients with anti-citrullinated protein antibody-positive rheumatoid arthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2015
Terao Chikashi, Suzuki Akari, Ikari Katsunori, Kochi Yuta, Ohmura Koichiro, Katayama Masaki, Nakabo Shuichiro, Yamamoto Natsuki, Suzuki Taku, Iwamoto Takuji, Yurugi Kimiko, Miura Yasuo, Maekawa Taira, Takasugi Kiyoshi, Kubo Michiaki, Saji Hiroh, Taniguchi Atsuo, Momohara Shigeki, Yamamoto Kazuhiko, Yamanaka Hisashi, Mimori Tsuneyo, Matsuda Fumihiko
Abstract excerpt
OBJECTIVE: Anti-citrullinated protein antibodies (ACPAs) are highly specific to rheumatoid arthritis (RA), and strong associations between HLA-DRB1 alleles and ACPA levels have been detected in RA patients. We undertook this study to elucidate the associations between particular amino acid positions in HLA-DRB1 and ACPA levels in patients with RA. METHODS: We analyzed ACPA data on a total of 4,371 Japanese...
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