Article

Sequencing of the MHC region defines <i>HLA-DQA1</i> as the major independent risk for anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis in Han population

2018-08-27

Abstract excerpt

<h4>ABSTRACT</h4> The strong genetic contribution of the major histocompatibility complex (MHC) to rheumatoid arthritis (RA) susceptibility has been generally attributed to HLA-DRB1 . However, due to the high linkage disequilibrium in the MHC region, it is difficult to define the ‘real’ or/and additional independent genetic risks using the conventional HLA genotyping or chip-based microarray technology. By the c...

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Literature Corpus work: 1f1c51ea-d933-5b43-b082-acf481756ac7
DOI: 10.1101/400937

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