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Article

Progranulin and TMEM106B: when two become wan.

EMBO reports - 5 Oct 2020

Clayton Emma L, Isaacs Adrian M

Abstract excerpt

Mutations in GRN, which encodes progranulin, are a common cause of familial frontotemporal dementia (FTD). FTD is a devastating disease characterised by neuronal loss in the frontal and temporal lobes that leads to changes in personality, behaviour and language. There are no effective treatments for this complex condition. TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. While the...

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Identifiers

PMID: 32985120
DOI: 10.15252/embr.202051668
PMCID: PMC7534635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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