Article
Losing protein in the brain: the case of progranulin.
Brain research - 2 Oct 2012
Ghidoni Roberta, Paterlini Anna, Albertini Valentina, Binetti Giuliano, Benussi Luisa
Abstract excerpt
It is well known that progranulin protein is involved in wound repair, inflammation, and tumor formation. The wedding between progranulin and brain was celebrated in 2006 with the involvement of progranulin gene (GRN) in Frontotemporal lobar degeneration (FTLD), the most common form of early-onset dementia: up to date, 75 mutations have been detected in FTLD patients as well as in patients with widely variable...
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