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Article

TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.

Journal of neurochemistry - 1 Sept 2013

Nicholson Alexandra M, Finch Nicole A, Wojtas Aleksandra, Baker Matt C, Perkerson Ralph B, Castanedes-Casey Monica, Rousseau Linda, Benussi Luisa, Binetti Giuliano, Ghidoni Roberta, Hsiung Ging-Yuek R, Mackenzie Ian R, Finger Elizabeth, Boeve Bradley F, Ertekin-Taner Nilüfer, Graff-Radford Neill R, Dickson Dennis W, Rademakers Rosa

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) is the second leading cause of dementia in individuals under age 65. In many patients, the predominant pathology includes neuronal cytoplasmic or intranuclear inclusions of ubiquitinated TAR DNA binding protein 43 (FTLD-TDP). Recently, a genome-wide association study identified the first FTLD-TDP genetic risk factor, in which variants in and around the TMEM106B gene (top...

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Identifiers

PMID: 23742080
DOI: 10.1111/jnc.12329
PMCID: PMC3766501

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.PMID 23742080Read ↗

Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.Semantic proximity Read ↗

TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.Semantic proximity Read ↗

TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.Semantic proximity Read ↗

What we know about TMEM106B in neurodegeneration.Semantic proximity Read ↗

Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration.Semantic proximity Read ↗

TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.Semantic proximity Read ↗

TMEM106B expression is reduced in Alzheimer’s disease brainsSemantic proximity Read ↗

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and functionSemantic proximity Read ↗

Granulin loss and TMEM106B risk converge on lysosomal C-terminal fragment pathology in frontotemporal dementiaSemantic proximity Read ↗

TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.Semantic proximity Read ↗

TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia.Semantic proximity Read ↗

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.Semantic proximity Read ↗

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