Article

Granulin loss and TMEM106B risk converge on lysosomal C-terminal fragment pathology in frontotemporal dementia

2026-03-26

Abstract excerpt

Frontotemporal dementia (FTD) is the second most common cause of dementia after Alzheimer disease. Mutations in GRN , which encodes progranulin, are a major cause of FTD. Common genetic variants in the TMEM106B gene modify risk of FTD and the effect is especially strong in GRN mutation carriers. Intriguingly, in GRN mutation carriers, being homozygous for the protective TMEM106B haplotype seems to confer near...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f8e8f8b4-a219-5db8-be69-3b51a7e8f63c
DOI: 10.64898/2026.03.25.713523

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Granulin loss and TMEM106B risk converge on lysosomal C-terminal fragment pathology in frontotemporal dementiaDOI 10.64898/2026.03.25.713523Read

Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulationSemantic proximity Read

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.Semantic proximity Read

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.Semantic proximity Read

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and functionSemantic proximity Read

Progranulin and TMEM106B: when two become wan.Semantic proximity Read

TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.Semantic proximity Read

Mechanisms of Granulin Deficiency: Lessons from Cellular and Animal ModelsSemantic proximity Read

Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels.Semantic proximity Read

What we know about TMEM106B in neurodegeneration.Semantic proximity Read

Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Semantic proximity Read

TMEM106B aggregation in neurodegenerative diseases: linking genetics to function.Semantic proximity Read

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.Semantic proximity Read