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Article

Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration.

The Journal of biological chemistry - 1 Jun 2012

Lang Christina M, Fellerer Katrin, Schwenk Benjamin M, Kuhn Peer-Hendrik, Kremmer Elisabeth, Edbauer Dieter, Capell Anja, Haass Christian

Abstract excerpt

TMEM106B was identified as a major risk factor in a genome-wide association study for frontotemporal lobar degeneration (FTLD) with TAR DNA-binding protein (TDP)-43 pathology. The most significant association of TMEM106B single nucleotide polymorphisms with risk of FTLD-TDP was observed in patients with progranulin (GRN) mutations. Subsequent studies suggested an inverse correlation between TMEM106B expression...

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Identifiers

PMID: 22511793
DOI: 10.1074/jbc.M112.365098
PMCID: PMC3365973

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration.PMID 22511793Read ↗

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