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Article

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.

Neuron - 19 Jul 2017

Klein Zoe A, Takahashi Hideyuki, Ma Mengxiao, Stagi Massimiliano, Zhou Melissa, Lam TuKiet T, Strittmatter Stephen M

Abstract excerpt

Progranulin (GRN) and TMEM106B are associated with several common neurodegenerative disorders including frontotemporal lobar degeneration (FTLD). A TMEM106B variant modifies GRN-associated FTLD risk. However, their functional relationship in vivo and the mechanisms underlying the risk modification remain unclear. Here, using transcriptomic and proteomic analyses with Grn-/- and Tmem106b-/- mice, we show that,...

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Brain
Frontotemporal Dementia
Intercellular Signaling Peptides and Proteins
Lysosomes
Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28728022
DOI: 10.1016/j.neuron.2017.06.026
PMCID: PMC5558861

Genes

GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.PMID 28728022Read ↗

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.Semantic proximity Read ↗

Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in miceSemantic proximity Read ↗

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and functionSemantic proximity Read ↗

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.Semantic proximity Read ↗

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.Semantic proximity Read ↗

Granulin loss and TMEM106B risk converge on lysosomal C-terminal fragment pathology in frontotemporal dementiaSemantic proximity Read ↗

Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.Semantic proximity Read ↗

What we know about TMEM106B in neurodegeneration.Semantic proximity Read ↗

Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulationSemantic proximity Read ↗

Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.Semantic proximity Read ↗

TMEM106B expression is reduced in Alzheimer’s disease brainsSemantic proximity Read ↗

Progranulin and TMEM106B: when two become wan.Semantic proximity Read ↗

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