Article
Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice
10 Aug 2020
Abstract excerpt
Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). Loss of PGRN leads to lysosome dysfunction during aging. TMEM106B, a gene encoding a lysosomal membrane protein, is the main risk factor for FTLD with PGRN haploinsufficiency. But how TMEM106B affects FTLD disease progression remains to be determined. Here, we report that TMEM106B deficiency in mice leads to...
Topics
Join the communities discussing this publication.