Article
TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.
Neurology - 1 Feb 2011
Finch N, Carrasquillo M M, Baker M, Rutherford N J, Coppola G, Dejesus-Hernandez M, Crook R, Hunter T, Ghidoni R, Benussi L, Crook J, Finger E, Hantanpaa K J, Karydas A M, Sengdy P, Gonzalez J, Seeley W W, Johnson N, Beach T G, Mesulam M, Forloni G, Kertesz A, Knopman D S, Uitti R, White C L, Caselli R, Lippa C, Bigio E H, Wszolek Z K, Binetti G, Mackenzie I R, Miller B L, Boeve B F, Younkin S G, Dickson D W, Petersen R C, Graff-Radford N R, Geschwind D H, Rademakers R
Abstract excerpt
OBJECTIVES: To determine whether TMEM106B single nucleotide polymorphisms (SNPs) are associated with frontotemporal lobar degeneration (FTLD) in patients with and without mutations in progranulin (GRN) and to determine whether TMEM106B modulates GRN expression. METHODS: We performed a case-contro...
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