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Frontotemporal dementia as a consequence of GRN mutations: From disease cause to models to therapies.

Pharmacological research - 1 Nov 2025

Salzano Sara, Bertasini Chiara, Tavakolian Haghighi Shima, Lundkvist Johan, Wahlberg Lars U, Chiamulera Cristiano, Vattemi Gaetano Na, Gardoni Fabrizio, Paolone Giovanna

Abstract excerpt

Frontotemporal dementia (FTD) encompasses a broad, clinically and neuropathologically diverse group of neurodegenerative disorders associated with changes in personality, behaviour, and/or language due to the progressive degeneration of the frontal and temporal lobes of the brain. Mutations in several genes, including the progranulin (PGRN) encoding gene (GRN), have been found to cause FTD. PGRN is a pleiotropic...

Topics

Humans
Frontotemporal Dementia
Progranulins
Animals
Mutation
Disease Models, Animal

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40972833
DOI: 10.1016/j.phrs.2025.107957

Genes

GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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