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The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function

6 Nov 2012

Abstract excerpt

Haploinsufficiency of Progranulin (PGRN), a gene encoding a secreted glycoprotein, is a major cause of frontotemporal lobar degeneration with ubiquitin (FTLD-U) positive inclusions. Single nucleotide polymorphisms in the TMEM106B gene were recently discovered as a risk factor for FTLD-U, especially in patients with PGRN mutations. TMEM106B is also associated with cognitive impairment in amyotrophic lateral...

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PMID: 23136129
DOI: 10.1093/hmg/dds475

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The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and functionPMID 23136129Read ↗

Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in miceSemantic proximity Read ↗

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.Semantic proximity Read ↗

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.Semantic proximity Read ↗

Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.Semantic proximity Read ↗

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Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.Semantic proximity Read ↗

What we know about TMEM106B in neurodegeneration.Semantic proximity Read ↗

TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.Semantic proximity Read ↗

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.Semantic proximity Read ↗

TMEM106B aggregation in neurodegenerative diseases: linking genetics to function.Semantic proximity Read ↗

Physiological and pathological functions of TMEM106B in neurodegenerative diseases.Semantic proximity Read ↗

Granulin loss and TMEM106B risk converge on lysosomal C-terminal fragment pathology in frontotemporal dementiaSemantic proximity Read ↗

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