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A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade.

Molecular cell - 15 Oct 2020

Yang Zhang-Hua, Wu Xiao-Nan, He Peng, Wang Xuekun, Wu Jianfeng, Ai Tingting, Zhong Chuan-Qi, Wu Xiurong, Cong Yu, Zhu Rongfeng, Li Hongda, Cai Zhi-Yu, Mo Wei, Han Jiahuai

Abstract excerpt

Necroptosis induction in vitro often requires caspase-8 (Casp8) inhibition by zVAD because pro-Casp8 cleaves RIP1 to disintegrate the necrosome. It has been unclear how the Casp8 blockade of necroptosis is eliminated naturally. Here, we show that pro-Casp8 within the necrosome can be inactivated by phosphorylation at Thr265 (pC8T265). pC8T265 occurs in vitro in various necroptotic cells and in the cecum of...

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PMID: 32979304
DOI: 10.1016/j.molcel.2020.09.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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