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Article

K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo.

Cell death and differentiation - 1 Oct 2016

Shutinoski B, Alturki N A, Rijal D, Bertin J, Gough P J, Schlossmacher M G, Sad S

Abstract excerpt

Receptor interacting protein kinase 1 (RIPK1) participates in several cell signaling complexes that promote cell activation and cell death. Stimulation of RIPK1 in the absence of caspase signaling induces regulated necrosis (necroptosis), which promotes an inflammatory response. Understanding of the mechanisms through which RIPK1 promotes inflammation has been unclear. Herein we have evaluated the impact of a...

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Source

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Identifiers

PMID: 27258786
DOI: 10.1038/cdd.2016.51
PMCID: PMC5041191

Genes

RIPK1
MIP
MLKL
RIPK3
STAT1
TNF

Provenance

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Related research

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K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo.PMID 27258786Read ↗

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