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Article

Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis.

Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2018

Meng Huyan, Liu Zhen, Li Xingyan, Wang Huibing, Jin Taijie, Wu Guowei, Shan Bing, Christofferson Dana E, Qi Chunting, Yu Qiang, Li Ying, Yuan Junying

Abstract excerpt

RIPK1 is a critical mediator of cell death and inflammation downstream of TNFR1 upon stimulation by TNFα, a potent proinflammatory cytokine involved in a multitude of human inflammatory and degenerative diseases. RIPK1 contains an N-terminal kinase domain, an intermediate domain, and a C-terminal death domain (DD). The kinase activity of RIPK1 promotes cell death and inflammation. Here, we investigated the...

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Identifiers

PMID: 29440439
DOI: 10.1073/pnas.1722013115
PMCID: PMC5834731

Genes

RIPK1

Variants

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Related research

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Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis.PMID 29440439Read ↗

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