Article

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal Homeostasis

2024-02-21

Abstract excerpt

The necroptosis mediated by RIPK3 is stringently regulated for intestinal homeostasis. Here we found that mice lacking Prmt5 (Protein arginase methyltransferase 5) in intestinal epithelial cells (IECs) caused premature death with IECs necroptosis, villus atrophy and loss of Paneth cells. This pathology can be partially rescued by antibiotic treatment, germ-free breeding condition and pharmaceutical inhibition of...

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Literature Corpus work: 5e6f3f6d-af2d-511d-9073-e09131603e9d
DOI: 10.1101/2024.02.21.581356

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