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Article

Atg14protects the intestinal epithelium from TNF-triggered villus atrophy

21 Mar 2019

Abstract excerpt

Regulation of intestinal epithelial turnover is a key component of villus maintenance in the intestine. The balance of cell turnover can be perturbed by various extrinsic factors including the cytokine TNF, a cell signaling protein that mediates both proliferative and cytotoxic outcomes. Under conditions of infection and damage, defects in autophagy are associated with TNF-mediated cell death and tissue damage in...

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PMID: 30894050
DOI: 10.1080/15548627.2019.1596495

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