The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis

Abstract excerpt

Receptor interacting protein kinase 1 (RIPK1) is a cytosolic multidomain protein that controls cell life and death. While RIPK1 promotes cell death through its kinase activity, it also functions as a scaffold protein to promote cell survival by inhibiting FADD-caspase 8-dependent apoptosis and RIPK3-MLKL-dependent necroptosis. This pro-survival function is highlighted by excess cell death and a perinatal lethality...

Topics

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• Adaptor Proteins, Vesicular Transport
• Cell Death
• Fas-Associated Death Domain Protein
• Inflammation
• Protein Domains
• Receptor-Interacting Protein Serine-Threonine Kinases
• Receptors, Tumor Necrosis Factor, Type I
• RNA-Binding Proteins

Identifiers and source

Literature Corpus work

da4707a7-4d63-5cae-920d-4df1939dcd70

DOI

10.1101/2021.02.27.433202