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Article

Necroptosis in development and diseases.

Genes & development - 1 Mar 2018

Shan Bing, Pan Heling, Najafov Ayaz, Yuan Junying

Abstract excerpt

Necroptosis, a form of regulated necrotic cell death mediated by RIPK1 (receptor-interacting protein kinase 1) kinase activity, RIPK3, and MLKL (mixed-lineage kinase domain-like pseudokinase), can be activated under apoptosis-deficient conditions. Modulating the activation of RIPK1 by ubiquitination and phosphorylation is critical to control both necroptosis and apoptosis. Mutant mice with kinase-dead RIPK1 or...

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Source

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Identifiers

PMID: 29593066
DOI: 10.1101/gad.312561.118
PMCID: PMC5900707

Genes

RIPK1
MLKL
RIPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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