Article
A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression.
eLife - 24 May 2021
Li Dianrong, Chen Jie, Guo Jia, Li Lin, Cai Gaihong, Chen She, Huang Jia, Yang Hui, Zhuang Yinhua, Wang Fengchao, Wang Xiaodong
Abstract excerpt
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) normally signals to necroptosis by phosphorylating MLKL. We report here that when the cellular RIPK3 chaperone Hsp90/CDC37 level is low, RIPK3 also signals to apoptosis. The apoptotic function of RIPK3 requires phosphorylation of the serine 165/threonine 166 sites on its kinase activation loop, resulting in inactivation of RIPK3 kinase activity while...
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