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Article

The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation.

Immunity - 9 Jul 2024

Imai Takashi, Lin Juan, Kaya Göksu Gökberk, Ju Eunjin, Kondylis Vangelis, Kelepouras Konstantinos, Liccardi Gianmaria, Kim Chun, Pasparakis Manolis

Abstract excerpt

RIPK1 is a multi-functional kinase that regulates cell death and inflammation and has been implicated in the pathogenesis of inflammatory diseases. RIPK1 acts in a kinase-dependent and kinase-independent manner to promote or suppress apoptosis and necroptosis, but the underlying mechanisms remain poorly understood. Here, we show that a mutation (R588E) disrupting the RIPK1 death domain (DD) caused perinatal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38744293
DOI: 10.1016/j.immuni.2024.04.016

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