Article
Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor.
Nature communications - 25 Sept 2020
Liu Jianlin, Adhav Ragini, Miao Kai, Su Sek Man, Mo Lihua, Chan Un In, Zhang Xin, Xu Jun, Li Jianjie, Shu Xiaodong, Zeng Jianming, Zhang Xu, Lyu Xueying, Pardeshi Lakhansing, Tan Kaeling, Sun Heng, Wong Koon Ho, Deng Chuxia, Xu Xiaoling
Abstract excerpt
Single-cell whole-exome sequencing (scWES) is a powerful approach for deciphering intratumor heterogeneity and identifying cancer drivers. So far, however, simultaneous analysis of single nucleotide variants (SNVs) and copy number variations (CNVs) of a single cell has been challenging. By analyzing SNVs and CNVs simultaneously in bulk and single cells of premalignant tissues and tumors from mouse and human...
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