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Article

Genome-wide analysis of somatic noncoding mutation patterns in cancer.

Science (New York, N.Y.) - 8 Apr 2022

Dietlein Felix, Wang Alex B, Fagre Christian, Tang Anran, Besselink Nicolle J M, Cuppen Edwin, Li Chunliang, Sunyaev Shamil R, Neal James T, Van Allen Eliezer M

Abstract excerpt

We established a genome-wide compendium of somatic mutation events in 3949 whole cancer genomes representing 19 tumor types. Protein-coding events captured well-established drivers. Noncoding events near tissue-specific genes, such as ALB in the liver or KLK3 in the prostate, characterized localized passenger mutation patterns and may reflect tumor-cell-of-origin imprinting. Noncoding events in regulatory...

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Identifiers

PMID: 35389777
DOI: 10.1126/science.abg5601
PMCID: PMC9092060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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