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Sinle-Cell Transcriptomics and Machine Learning Algorithms Unveil Metastasis-Associated Cellular Subtypes and Prognostic Signatures in Colorectal Cancer

2025-04-23

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<title>Abstract</title> <p>Background Colorectal cancer (CRC) is a prevalent digestive tract malignancy, with liver metastasis occurring in up to 50% of cases. Identifying reliable early metastasis markers is crucial for improving CRC prognosis. Methods In this study, we analyzed single-cell RNA sequencing data from CRC patients, including primary tumors, adjacent normal tissues, and liver metastases. Copy numb...

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Literature Corpus work
dc053a91-68dc-595e-b06e-adf020391770
DOI
10.21203/rs.3.rs-6479548/v1
Open publication

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