Article
Pan-cancer whole-genome analyses of metastatic solid tumours.
Nature - 1 Nov 2019
Priestley Peter, Baber Jonathan, Lolkema Martijn P, Steeghs Neeltje, de Bruijn Ewart, Shale Charles, Duyvesteyn Korneel, Haidari Susan, van Hoeck Arne, Onstenk Wendy, Roepman Paul, Voda Mircea, Bloemendal Haiko J, Tjan-Heijnen Vivianne C G, van Herpen Carla M L, Labots Mariette, Witteveen Petronella O, Smit Egbert F, Sleijfer Stefan, Voest Emile E, Cuppen Edwin
Abstract excerpt
Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A better understanding of the characteristics of late-stage cancer is required to help adapt personalized treatments, reduce overtreatment and improve outcomes. Here we describe the largest, to our knowledge, pan-cancer study of metastatic solid tumour genomes, including whole-genome sequencing data for 2,520 pairs of...
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