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Article

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.

Nature - 11 May 2017

Merkle Florian T, Ghosh Sulagna, Kamitaki Nolan, Mitchell Jana, Avior Yishai, Mello Curtis, Kashin Seva, Mekhoubad Shila, Ilic Dusko, Charlton Maura, Saphier Genevieve, Handsaker Robert E, Genovese Giulio, Bar Shiran, Benvenisty Nissim, McCarroll Steven A, Eggan Kevin

Abstract excerpt

Human pluripotent stem cells (hPS cells) can self-renew indefinitely, making them an attractive source for regenerative therapies. This expansion potential has been linked with the acquisition of large copy number variants that provide mutated cells with a growth advantage in culture. The nature, extent and functional effects of other acquired genome sequence mutations in cultured hPS cells are not known. Here we...

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Identifiers

PMID: 28445466
DOI: 10.1038/nature22312
PMCID: PMC5427175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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