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Article

Spontaneous Single-Copy Loss of TP53 in Human Embryonic Stem Cells Markedly Increases Cell Proliferation and Survival.

Stem cells (Dayton, Ohio) - 1 Apr 2017

Amir Hadar, Touboul Thomas, Sabatini Karen, Chhabra Divya, Garitaonandia Ibon, Loring Jeanne F, Morey Robert, Laurent Louise C

Abstract excerpt

Genomic aberrations have been identified in many human pluripotent stem cell (hPSC) cultures. Commonly observed duplications in portions of chromosomes 12p and 17q have been associated with increases in genetic instability and resistance to apoptosis, respectively. However, the phenotypic consequences related to sporadic mutations have not been evaluated to date. Here, we report on the effects of a single-copy...

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Identifiers

PMID: 27888558
DOI: 10.1002/stem.2550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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