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Article

Mutations of the Kirsten-ras proto-oncogene in human preleukaemia.

Nature - 1 Jan 2000

Liu E, Hjelle B, Morgan R, Hecht F, Bishop J M

Abstract excerpt

The myelodysplastic syndrome (MDS) or preleukaemia is a haematological disorder characterized by low blood counts, bone marrow cells of abnormal appearance and progression to acute leukaemia in as many as 30% of patients. The distinctive preleukaemic and leukaemic phases of this disease make it an attractive model for neoplastic progression in human tumours. We reasoned that, because dominantly transforming genes...

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Identifiers

PMID: 3313061
DOI: 10.1038/330186a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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